Expression of the 1918 Influenza A Virus PB1-F2 Enhances the Pathogenesis of Viral and Secondary Bacterial Pneumonia
Identifieur interne : 001379 ( Main/Exploration ); précédent : 001378; suivant : 001380Expression of the 1918 Influenza A Virus PB1-F2 Enhances the Pathogenesis of Viral and Secondary Bacterial Pneumonia
Auteurs : Julie L. Mcauley [États-Unis] ; Felicita Hornung [États-Unis] ; Kelli L. Boyd [États-Unis] ; Amber M. Smith [États-Unis] ; Raelene Mckeon [États-Unis] ; Jack Bennink [États-Unis] ; Jonathan W. Yewdell [États-Unis] ; Jonathan A. Mccullers [États-Unis]Source :
- Cell host & microbe [ 1931-3128 ] ; 2007.
Abstract
Secondary bacterial pneumonia frequently claimed the lives of victims during the devastating 1918 influenza A virus pandemic. Little is known about the viral factors contributing to the lethality of the 1918 pandemic. Here we show that expression of the viral accessory protein PB1-F2 enhances inflammation during primary viral infection of mice and increases both the frequency and severity of secondary bacterial pneumonia. The priming effect of PB1-F2 on bacterial pneumonia could be recapitulated in mice by intranasal delivery of a synthetic peptide derived from the C-terminal portion of the PB1-F2. Relative to its isogenic parent, an influenza virus engineered to express a PB1-F2 with coding changes matching the 1918 pandemic strain was more virulent in mice, induced more pulmonary immunopathology, and led to more severe secondary bacterial pneumonia. These findings help explain both the unparalleled virulence of the 1918 strain and the high incidence of fatal pneumonia during the pandemic.
Url:
DOI: 10.1016/j.chom.2007.09.001
PubMed: 18005742
PubMed Central: 2083255
Affiliations:
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Mcauley</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea> Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Hornung, Felicita" sort="Hornung, Felicita" uniqKey="Hornung F" first="Felicita" last="Hornung">Felicita Hornung</name><affiliation wicri:level="2"><nlm:aff id="A2"> Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Boyd, Kelli L" sort="Boyd, Kelli L" uniqKey="Boyd K" first="Kelli L." last="Boyd">Kelli L. 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Yewdell</name><affiliation wicri:level="2"><nlm:aff id="A2"> Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A." last="Mccullers">Jonathan A. Mccullers</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea> Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis</wicri:cityArea></affiliation></author></analytic><series><title level="j">Cell host & microbe</title><idno type="ISSN">1931-3128</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Secondary bacterial pneumonia frequently claimed the lives of victims during the devastating 1918 influenza A virus pandemic. Little is known about the viral factors contributing to the lethality of the 1918 pandemic. Here we show that expression of the viral accessory protein PB1-F2 enhances inflammation during primary viral infection of mice and increases both the frequency and severity of secondary bacterial pneumonia. The priming effect of PB1-F2 on bacterial pneumonia could be recapitulated in mice by intranasal delivery of a synthetic peptide derived from the C-terminal portion of the PB1-F2. Relative to its isogenic parent, an influenza virus engineered to express a PB1-F2 with coding changes matching the 1918 pandemic strain was more virulent in mice, induced more pulmonary immunopathology, and led to more severe secondary bacterial pneumonia. These findings help explain both the unparalleled virulence of the 1918 strain and the high incidence of fatal pneumonia during the pandemic.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li><li>Tennessee</li><li>Utah</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Mcauley, Julie L" sort="Mcauley, Julie L" uniqKey="Mcauley J" first="Julie L." last="Mcauley">Julie L. Mcauley</name></region><name sortKey="Bennink, Jack" sort="Bennink, Jack" uniqKey="Bennink J" first="Jack" last="Bennink">Jack Bennink</name><name sortKey="Boyd, Kelli L" sort="Boyd, Kelli L" uniqKey="Boyd K" first="Kelli L." last="Boyd">Kelli L. Boyd</name><name sortKey="Hornung, Felicita" sort="Hornung, Felicita" uniqKey="Hornung F" first="Felicita" last="Hornung">Felicita Hornung</name><name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A." last="Mccullers">Jonathan A. Mccullers</name><name sortKey="Mckeon, Raelene" sort="Mckeon, Raelene" uniqKey="Mckeon R" first="Raelene" last="Mckeon">Raelene Mckeon</name><name sortKey="Smith, Amber M" sort="Smith, Amber M" uniqKey="Smith A" first="Amber M." last="Smith">Amber M. Smith</name><name sortKey="Yewdell, Jonathan W" sort="Yewdell, Jonathan W" uniqKey="Yewdell J" first="Jonathan W." last="Yewdell">Jonathan W. Yewdell</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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